Curtis Thorne, PhD, and colleagues published a new study in Developmental Cell describing a simple, scalable method to culture 2D enteroid monolayers that, surprisingly, recapitulates many of the features of in vivo intestinal tissue and can be used for high-throughput microscopy-based experiments. Using this system, they systematically perturb WNT and BMP signals to reveal a core morphogenic circuit that controls proliferation, tissue organization, and cell fate or the intestine.
