Adam Watson, Gus Mouneimne, and a cadre of stellar collaborators in CMM and beyond, demonstrate that the stiffness of the tumor microenvironment can persistently alter cancer cell behavior, even after dissemination to softer microenvironments, by a process termed “mechanical memory.” Mechanical conditioning by stiff microenvironments promotes invasion and osteolysis, and this study develops a mechanical conditioning (MeCo) score associated with bone metastasis in patients.
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https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00664-1