Dr. Henk Granzier was recently awarded a 4 year, $2 million grant from the National Heart, Lung, and Blood Institute (NHLBI). His grant, entitled “Titin-based adaptations of cardiac function” focuses on studying the mechanistic basis by with mutations in the giant protein titin result in dilated cardiomyopathy (DCM). DCM is a major cause of death, yet understanding the underlying mechanisms is still limited and treatment options are few at best. Mutations in titin are a common cause of DCM and the proposed work in this grant has high clinical relevance.
