In a recent study led by UA Assistant Professor Casey Romanoski, PhD, the research team used genome-wide epigenetics to identify major drivers of human artery endothelial cell responses to inflammatory environments. They utilized endothelial genome sequences called enhancers to pinpoint DNA variation in humans that may underpin differential susceptibility to coronary artery disease. Their findings, published June 6th in eLIFE (https://elifesciences.org/articles/22536), improve our understanding of vascular biology and moves us one step closer to understanding the molecular mechanisms of disease.
